The human epidermis, or skin as it is commonly called, is the largest organ within the human body and it self-renews throughout a person’s lifetime. Laboratory researchers have discovered that the activation of telomerase has a primary role in maintaining the skin’s proper function as well as in augmenting its renewal. (Telomerase is an enzyme that repairs the tips of chromosomes which otherwise get shorter as humans age. The chromosome tips, called telomeres, make the skin look older as the telomeres approach the end of their life cycle. In fact, it only takes approximately 50 replications of the DNA within the body’s skin cells before the skin begins to show visible signs of aging. Without intervention, eventually the cell degrades to the point that the DNA inside it can no longer replicate. This is a primary cause of aged and wrinkled skin.
At the National Institutes of Health (NIH), researchers have reported in the Journal of Clinical Investigation the identification of a new means by which to “set a clock” for the programmed aging in healthy skin, as well as in other cells. Their research focuses upon the interaction between progerin and telomeres. Progerin is a toxic protein., a mutated type of the normal cell protein known as lamin A, which is found within the coding of the healthy LMNA gene. Lamin A maintains the health of a cell’s nucleus, which is where the DNA is kept. Progerin is one of the primary components of normal aging. The researchers discovered that short and/or dysfunctional telomeres can activate progerin production, which accelerates cellular damage related to age. As the chromosome tips naturally shorten, they make more and more progerin. According to Kan Cao, Ph.D., an assistant professor of cellular biology and as well as molecular genetics at the University of Maryland, this then disrupts the manner in which other alternative genes splice. It is currently thought that this combination of progerin production with telomere shortening and fraying are together responsible for the visible signs of cellular aging. Therefore this study is an insightful glimpse into the ways in which progerin might participate in the normal human aging process.
Words such as telomeres telomerase might sound a bit futuristic, but they are very much a part of the current scientific investigative platform, particularly where their affect on cellular aging is concerned. Telomerase is a ribonucleoprotein type enzyme with the power to extend the telomeres for the purpose of allowing the cells to continue to replicate. Cells that are provided a constant intake of telomerase produce very little progerin RNA and therefore age very little. Each time the telomeres are ready to split from the cell as it divides in two the telomerase fills the gap and re-lengthens the telomeres, which in turn sustains the cell’s life. At this time it appears the only way to lengthen telomeres is via telomerase arousal. In practical terms so far as appearance is concerned, this means that supplementation with CA-98 will support to tighten your skin, make your crows feet go away, and reduce wrinkles, age spots and will also restore lost moisture and plumpness to the skin.
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